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Better Sleep

Pain Relief

Decreased Stress

Improved Immunity

Learn more about our 4 Board-Certified MD founders

Learn how MDbio products restore your endocannabinoid balance and maximize health

MDcalm

The scientifically-tested supplement to calm your body and ease your mind.

Doctor
fomulated

Patient

tested

Sustainably
sourced

Cruelty

free

Non

intoxicating

Non
GMO

Calm feelings of uneasiness naturally

“It is not sedating, but offers a noticeable effect on the discomfort.”

— Holly H.

  • Full spectrum hemp
  • Premium plant-based ingredients
  • Hundreds of phytochemicals
  • Doctor-developed optimal blend
  • Tested with real patients
  • Safe alternative pharmaceuticals
  • Not psychoactive
  • Restores balance
  • Supports internal ECS system
  • Premium plant-based ingredients
  • Hundreds of phytochemicals
  • Doctor-developed optimal blend
  • Tested with real patients
  • Safe alternative pharmaceuticals
  • Not psychoactive
  • Restores balance

Proven results

The efficacy of MDcalm + hemp formula has been scientifically proven through observational studies and is currently in clinical trial.

The efficacy of MDcalm botanical blend has been scientifically proven through observational studies.

In an observational study

91%
Reported a positive experience

Within 10 days

Our observational study

In an observational study

99%+
Reported a positive experience

Within 10 days

Our observational study

Our ingredient list

MDcalm + hemp formula is made of sustainably sourced, non-intoxicating ingredients containing hundreds of phytochemicals.

MDcalm botanical blend is made of sustainably sourced, non-intoxicating ingredients containing hundreds of phytochemicals.

Check out our MDcalm botanical blend that features our proprietary calm complex and bio-terpene complex.

See botanical blend


*MDcalm botanical blend does not contain full spectrum hemp.

Check out our MDcalm + hemp formula that includes full spectrum hemp.

See + hemp

Our solutions work with

The endocannabinoid system.

Discovered in in the 1990s, the Endocannabinoid system (ECS) is a sophisticated biological “control system.”

It is a complex matrix of cell receptors, neurotransmitters and enzymes that all work together to maintain homeostasis.

The largest system of biochemical receptors in our body, ECS is made of 3 parts:

Endocannabinoids in our body interact with specific parts of our cells called endocannabinoid receptors. These receptors are found on different types of cells in our body and can cause different reactions when activated. Scientists have studied two of these receptors of importance for the effects of endocannabinoids.

  • Cannabinoid 1 (CB1) Receptors: They are primarily found in the central nervous system, especially in neurons or nerve cells in the brain. Anandamide also binds with these receptors.
  • Cannabinoid 2 (CB2) Receptors: Found in the peripheral nervous system and immune cells. They are like tiny keyholes unlocked by molecules called 2-AG. The CB2 receptors can help reduce inflammation and other immune responses.

Endocannabinoids are natural chemicals our bodies make, similar to those found in cannabis plants. Our body produces endocannabinoids when required rather than in advance. The nervous system uses these chemicals to communicate with different body parts. 

Your body can produce these chemicals because they come from fats – everyone has an active ECS system. Dr. Larian outlines the role of an endocannabinoid in regulating nervous impulses: “When these nerves feel that the previous nerve is firing too hard… the extra input sends an endocannabinoid. This extra chemical… …goes backward and tells the nerve, ‘Calm down. You’re working too hard. Go back to your baseline and restart.’” 

Scientists have extensively researched two significant types of endocannabinoids: 

  • The messenger or "bliss" molecule: Arachidonoyl ethanolamide (anandamide or AEA)
  • 2-AG: 2-arachidonoyl glycerol enhances the function of CB1 receptors and is the primary natural molecule that can bind to CB2 receptors.

Enzymes are natural substances our bodies produce to create and break down certain chemicals. For example, when a cell needs to send a message, endocannabinoids are made by breaking down fats with the help of enzymes. After the endocannabinoids do their job, they are removed from the cells by a particular protein and broken down further by other enzymes. Regarding endocannabinoids, two types of enzymes help break them down so they don't stay in our body for too long: 

  • Fatty acid amide hydrolase (FAAH): findings suggest that FAAH has a natural ability to break down anandamide and 2-AG.
  • Monoacylglycerol acid lipase (MAG-L): Once the 2-AG molecule has completed its function, it is taken back into the cells and broken down by an enzyme called MAGL. The body uses the broken-down product to produce other compounds.


Understanding how these enzymes work could help create new treatments for diseases like addiction.

Learn more
219 Reviews
Real reviews by real people who take MDcalm
average rating 4.9 out of 5
Based on 219 reviews
  • 5 Stars
    204 Reviews
  • 4 Stars
    14 Reviews
  • 3 Stars
    0 Reviews
  • 2 Stars
    0 Reviews
  • 1 Star
    1 Review
Review posted
Reviewed by Steve L.
Verified Buyer
MDcalm
Reviewing
MDcalm
Age Range
55 - 64
Symptoms
  • Sleeplessness
Rated 1 out of 5

Steve Little

I’m still trying but so far no improvement

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I don't recommend this product
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Review posted
Reviewed by Patricia M.
Verified Buyer
MDcalm
Reviewing
MDcalm
Age Range
65+
Rated 5 out of 5

It works

Occasionally I take these pills when I am stressed out. I can really feel them working on me and relaxing me. Sometimes I take them an hour before I go to bed and they help me sleep.

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Review posted
Reviewed by Alice
MDcalm
Reviewing
MDcalm
Age Range
25 - 34
Symptoms
  • Anxiety
Product Qualities
  • Fast-Acting
  • Effective
  • Does the Job
Rated 5 out of 5

Excellent natural remedy to anxiety

This product exceeded my expectations. After I took it, I could almost immediately feel a wave of calmness. It’s also a safe and healthy alternative to traditional medication which can have a lot of side effects. I would recommend this to those who suffer from anxiety.

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Ask Us Anything.


We’re an Open Book.

We put a lot of thought into creating these optimal blends for top conditions. Our team of doctors and experts are happy to answer your questions.

Truthfully, anytime! But we recommend you pop MDcalm with a meal. Digesting food gets those natural ingredients on the move faster.

Every body has its own universe. Start with 2 softgels for 3 days, and then adjust depending on how you have felt. If you need an extra softgel with each dose because two wasn’t doing the trick, take 3. If you have been experiencing mild side effects such as grogginess, decrease to 1 softgel per dose. The key to finding a therapeutic dose of MDbio products is through consistency. 

"Full Spectrum" is our way of saying we're embracing all the good stuff from the hemp plant. It’s like a team: everyone brings something unique to the table. And just like our bodies have evolved over ages with a built-in system (the “endocannabinoid” system) that touches everything we do, we believe that harnessing the full power of hemp makes the perfect tag team.

Breathe! Sometimes nature takes a minute.. A steady 3-day waltz might do the trick. And peek at those dosing guidelines to tune your steps.

Nope! MDcalm's like a gentle lullaby without the snooze button. Want some Zzz's? That's a job for our MDsleep.

This is a question for your primary care physician. Have a chat with your doctor to make sure you’re in the clear.

Talk with a live support agent by clicking on the bubble in the bottom right hand screen

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