icon

Search

Better Sleep

Pain Relief

Decreased Stress

Improved Immunity

Learn more about our 4 Board-Certified MD founders

Learn how MDbio products restore your endocannabinoid balance and maximize health

MDcalm

+hemp

The scientifically-tested supplement to calm your body and ease your mind.

Clinically Proven Formula

Includes Full Spectrum Hemp

Non-intoxicating & non-drowsy

15% off on all subscription orders

Reschedule, hold, or cancel at any time

Free standard shipping

30-day money-back guarantee

Product Details

Ingredient List

How to Use

Take 2 softgels at the start of your day or at any point you feel an onset of stress or anxiety. You may take up to 6 softgels per day 4-6 hours apart. See our full dosing guidelines here.

MDcalm

MDcalm™ Hemp Blend
MDcalm™ Hemp Blend
MDcalm™ Hemp Blend
MDcalm™ Hemp Blend
MDcalm™ Hemp Blend
MDcalm™ Hemp Blend
MDcalm

Balance your mood, naturally

MDcalm +hemp is a daytime, non-drowsy, non-intoxicating calming mind and body supplement. It combines full spectrum hemp with magnesium and a botanical blend of adaptogens to ease everyday stress and anxiety.

Why MDcalm?

  • Includes full spectrum hemp
  • Non-psychoactive
  • Clinically tested
  • Activates the endocannabinoid system
  • Promotes relaxation

Our Formulas

  • Made with quality time tested herbs, botanicals and minerals
  • Helps calm the central nervous system
  • Quiets the mind
  • Eases muscular tension

Scientifically formulated
to balance mood

MDcalm +hemp supports stress relief and occasional anxiety by relaxing the mind and the body without causing drowsiness.

Full Spectrum Hemp
a clinical, non-intoxicating dose (less than 0.3 THC) activates the endocannabinoid system that regulates physiological and cognitive processes including the sleep cycle, the circadian rhythm and responses to stress and mood.
Lavender
a powerhouse of plant medicine that supports the central nervous system and promotes feelings of calm and relaxation.
Mint
a time-tested herb that improves alertness, boosts overall mood, and relieves muscle tension.
Magnesium
a key mineral that supports muscle and nerve relaxation.
Ashwagandha and Reishi Mushrooms
centuries-old adaptogens that help the body cope with stress and anxiety by helping modulate cortisol and support the central nervous system.

Proven Results

The efficacy of MDcalm +hemp formula has been scientifically proven through observational studies and a double-blind placebo-controlled clinical trial.

We invested in the largest 'feelings of anxiety' supplement clinical trial in history with 1,948 participants

Our ingredient list

MDcalm + hemp formula is made of sustainably sourced, non-intoxicating ingredients containing hundreds of phytochemicals.

MDcalm botanical blend is made of sustainably sourced, non-intoxicating ingredients containing hundreds of phytochemicals.

Check out our MDcalm botanical blend that features our proprietary calm complex and bio-terpene complex.

See botanical blend


*MDcalm botanical blend does not contain full spectrum hemp.

Check out our MDcalm + hemp formula that includes full spectrum hemp.

See + hemp

Our solutions work with

The endocannabinoid system.

Our solutions work with the endocannabinoid system. Discovered in the 1990’s, the Endocannabinoid System (ECS) is a sophisticated biological “control system”. 

Is it a complex matrix of cell receptors, neurotransmitters and enzymes that all work together to maintain homeostasis. 

The largest system of biochemical receptors in our body, ECS is make of 3 parts:

Endocannabinoids in our body interact with specific parts of our cells called endocannabinoid receptors. These receptors are found on different types of cells in our body and can cause different reactions when activated. Scientists have studied two of these receptors of importance for the effects of endocannabinoids.

  • Cannabinoid 1 (CB1) Receptors: They are primarily found in the central nervous system, especially in neurons or nerve cells in the brain. THC and anandamide also bind with these receptors.
  • Cannabinoid 2 (CB2) Receptors: Found in the peripheral nervous system and immune cells. They are like tiny keyholes unlocked by molecules called 2-AG. The CB2 receptors can help reduce inflammation and other immune responses.

Endocannabinoids are natural chemicals our bodies make, similar to those found in cannabis plants. Our body produces endocannabinoids when required rather than in advance. The nervous system uses these chemicals to communicate with different body parts.

Your body can produce these chemicals because they come from fats – everyone has an active ECS system. Dr. Larian outlines the role of an endocannabinoid in regulating nervous impulses: “When these nerves feel that the previous nerve is firing too hard… the extra input sends an endocannabinoid. This extra chemical… …goes backward and tells the nerve, ‘Calm down. You’re working too hard. Go back to your baseline and restart.’”

Scientists have extensively researched two significant types of endocannabinoids: 

  • The messenger or "bliss" molecule: Arachidonoyl ethanolamide (anandamide or AEA)
  • 2-AG: 2-arachidonoyl glycerol enhances the function of CB1 receptors and is the primary natural molecule that can bind to CB2 receptors.

Enzymes are natural substances our bodies produce to create and break down certain chemicals. For example, when a cell needs to send a message, endocannabinoids are made by breaking down fats with the help of enzymes. After the endocannabinoids do their job, they are removed from the cells by a particular protein and broken down further by other enzymes. Regarding endocannabinoids, two types of enzymes help break them down so they don't stay in our body for too long: 


  • Fatty acid amide hydrolase (FAAH): findings suggest that FAAH has a natural ability to break down anandamide and 2-AG.
  • Monoacylglycerol acid lipase (MAG-L): Once the 2-AG molecule has completed its function, it is taken back into the cells and broken down by an enzyme called MAGL. The body uses the broken-down product to produce other compounds.


Understanding how these enzymes work could help create new treatments for diseases like addiction.

Learn more

Looking for our
botanical blend?

MDcalmTM botanical

It combines a harmonizing blend of traditionally time-tested herbs with key amino acids to promote and prolong restful sleep.

Shop now

Still unsure about choosing
hemp or botanical?

221 Reviews
Real reviews by real people who take MDcalm

average rating 4.9 out of 5
Based on 221 reviews
  • 5 Stars
    205 Reviews
  • 4 Stars
    15 Reviews
  • 3 Stars
    0 Reviews
  • 2 Stars
    0 Reviews
  • 1 Star
    1 Review
221 Reviews
Reviewed by Gina B.
Verified Buyer
MDcalm
Reviewing
MDcalm
I recommend this product
Age Range
55 - 64
Symptoms
  • Anxiety
Product Qualities
  • Effective
  • Helpful
Rated 5 out of 5
Review posted

Just what I needed!

This does what it says it will do!

Loading...
Was this helpful?
Reviewed by Rick T.
Verified Buyer
MDcalm Hemp
Reviewing
MDcalm Hemp
I recommend this product
Age Range
65+
Symptoms
  • Sleeplessness
  • Anxiety
Product Qualities
  • Useful
Rated 4 out of 5
Review posted

Using MDcalm

I’m just getting to learn how to help improve my quality of Life with selective use of MDcalm Hemp! I need more time to do so? Ask me after I have more experience using it…Thanks For Asking!

Loading...
Was this helpful?
Reviewed by Steve L.
Verified Buyer
MDcalm
Reviewing
MDcalm
I don't recommend this product
Age Range
55 - 64
Symptoms
  • Sleeplessness
Rated 1 out of 5
Review posted

Steve Little

I’m still trying but so far no improvement

Loading...
Was this helpful?

Ask Us Anything.

We’re an Open Book.

We put a lot of thought into creating these optimal blends for top conditions. Our team of doctors and experts are happy to answer your questions.

When should I take MDcalm?

Truthfully, anytime! But we recommend you pop MDcalm with a meal. Digesting food gets those natural ingredients on the move faster.

How much should I take?

Every body has its own universe. Start with 2 softgels for 3 days, and then adjust depending on how you have felt. If you need an extra softgel with each dose because two wasn’t doing the trick, take 3. If you have been experiencing mild side effects such as grogginess, decrease to 1 softgel per dose. The key to finding a therapeutic dose of MDbio products is through consistency.

Why did you add Full Spectrum Hemp to MDcalm and what does it do?

"Full Spectrum" is our way of saying we're embracing all the good stuff from the hemp plant. It’s like a team: everyone brings something unique to the table. And just like our bodies have evolved over ages with a built-in system (the “endocannabinoid” system) that touches everything we do, we believe that harnessing the full power of hemp makes the perfect tag team.

What if I still feel anxious after my first day of use?

Breathe! Sometimes nature takes a minute.. A steady 3-day waltz might do the trick. And peek at those

Will this product make me drowsy?

Nope! MDcalm's like a gentle lullaby without the snooze button. Want some Zzz's? That's a job for our

Will this product interfere with my current medications?

This is a question for your primary care physician. Have a chat with your doctor to make sure you’re in the clear.

I have more questions

Talk with a live support agent by clicking on the bubble in the bottom right hand screen

Your lingering issues, solved

Put an end to your discomfort

MDcalm

TM

The scientifically-tested supplement to calm your body and ease your mind.

Learn More

MDsleep

TM

The clinically-proven supplement to help you get a good night’s sleep.

Learn More