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Key Takeaways

  • CBD is a non-psychoactive compound found in cannabis plants with potential therapeutic effects.
  • It interacts with the endocannabinoid system to produce its effects, and can be consumed through various forms like oils, capsules and edibles.
  • Before taking CBD it’s important to consider drug interactions & find the right dosage for individual needs by consulting a healthcare professional.

Have you ever wondered how CBD, a compound found in cannabis plants, can offer such a wide range of potential therapeutic benefits without causing a “high”? In this blog post, we’ll take you on a journey to uncover the benefits of CBD and how does CBD work within our body. Get ready to explore the fascinating world of CBD and its interaction with our endocannabinoid system, as well as its potential impact on pain, inflammation, and mental health.

Understanding CBD: A Brief Overview

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CBD, short for cannabidiol, is a non-psychoactive compound found in cannabis plants, including the marijuana plant used for medical marijuana and medical cannabis. Unlike THC, another compound found in cannabis, CBD won’t get you high. CBD has gained popularity for its potential therapeutic effects, including:

  • Pain relief
  • Reduction of anxiety and depression symptoms
  • Alleviation of cancer-related symptoms
  • Neuroprotective properties
  • Anti-inflammatory effects With CBD legal in many places, it has become a popular option for those seeking natural remedies. Many people wonder how does CBD work for pain relief and other ailments.

The legal status of CBD in the US depends on its source: if it’s derived from hemp, it’s legal, but if it’s derived from marijuana, it’s not. CBD products come in various forms, such as CBD oil, which is created by extracting CBD from the marijuana or hemp plant and mixing it with a carrier oil like coconut oil or hemp seed oil. Combining CBD with other phytocannabinoids and terpenoids can enhance its potency and effectiveness.

The Endocannabinoid System: CBD's Target

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The endocannabinoid system (ECS) is a complex cell-signaling system that is integral to maintaining homeostasis in our bodies. It’s composed of endocannabinoids and their receptors, which help regulate various physiological processes, such as mood, appetite, and sleep. CBD interacts with the ECS to exert its therapeutic effects, potentially benefiting those with sleep disorders.

Comprehending the specific cannabinoid receptors that CBD interacts with paves the way for unlocking its medical uses and conducting successful clinical trials. The upcoming sections will provide a more detailed insight into the primary receptors in the ECS and the ways in which endocannabinoids and phytocannabinoids, including CBD, interact with them.

CB1 and CB2 Receptors

CB1 and CB2 receptors are the two main receptors in the endocannabinoid system (ECS) and respond to endocannabinoids and phytocannabinoids like CBD. CB1 receptors are primarily located in the brain, while CB2 receptors are mainly found in immune cells and peripheral tissues. CBD works by interacting with these receptors to produce various therapeutic effects, such as potentially helping with conditions like multiple sclerosis.

The structure of CB1 and CB2 receptors consists of a 7-transmembrane (7TM) bundle and an intracellular amphipathic helix. When cannabinoids, like those found in CBD products, bind to these receptors, they can influence different bodily functions and create therapeutic effects.

Endocannabinoids and Phytocannabinoids

Endocannabinoids are compounds naturally produced in our bodies, while phytocannabinoids, such as CBD, are derived from plants. Although their structures can differ, they both interact with the same receptors in our body, the CB1 and CB2 receptors, to produce various physiological effects. This interaction helps maintain the balance of different processes in our body.

The major types of endocannabinoids produced by our body include anandamide (AEA) and 2-arachidonoyl glycerol (2-AG). Both endocannabinoids and phytocannabinoids play a role in helping with conditions like chronic pain, as they interact with the ECS to control different body functions.

CBD's Impact on Pain and Inflammation

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CBD has shown potential in reducing pain and inflammation through its interaction with pain-sensing receptors and its regulation of the immune response. In fact, CBD may help with inflammatory and neuropathic pain by suppressing the production of cytokines, which results in a reduction of inflammation caused by the immune system.

The TRPV1 receptor plays an important role in controlling body temperature. It is also known as a heat and pain-sensing receptor. CBD has the potential to “desensitize” the TRPV1 receptor, which may contribute to its pain-relieving properties.

Proceeding sections will examine the potential impact of CBD on specific pain types, including neuropathic and arthritis-related joint pain.

Neuropathic Pain Relief

Neurons play an important role in transmitting pain signals from one part of the body to the brain. Damage to these nerves can lead to neuropathic pain. CBD may help alleviate this type of pain by modulating pain signals and desensitizing pain receptors. A 2017 review showed that CBD can be a great relief for people with chronic neuropathy pain, effectively relieving chronic pain. The findings of the investigation indicated its effectiveness in providing soothing sensations to humans.

However, a Cochrane review from 2018 on cannabis-based medicine for chronic neuropathic pain concluded that the potential benefits might not be worth the potential risks. More research is necessary to gain a comprehensive comprehension of CBD’s role in the management of chronic neuropathic pain. This includes exploring the potential risks, benefits, and ideal dosages associated with it.

Arthritis and Joint Pain

CBD has shown promise in reducing arthritis and joint pain by decreasing inflammation and improving mobility in animal studies. One study found that 36% of respondents who used CBD for arthritis and joint pain reported it to be effective. Additionally, associations have been found between CBD use and improvements in arthritis symptoms and reductions in other medications.

However, more research is needed to fully understand the effects of CBD on arthritis and joint pain. The potential benefits of CBD in targeting synovial fibroblasts under inflammatory conditions and its anti-arthritic activity could help reduce inflammation and the pain associated with acute arthritic pain.

CBD's Role in Mental Health

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CBD may have a positive impact on mental health by interacting with serotonin receptors in the brain, specifically the serotonin 1A (5-HT1A) receptor. Clinical studies have shown that CBD can activate the 5-HT1A receptor, which may contribute to its analgesic and anxiolytic effects. Additionally, experimental evidence suggests that CBD induces anxiolytic and antiepileptic effects through the activation of 5-HT1A receptors.

This interaction with serotonin receptors could be the reason why CBD is such an effective antidepressant, anxiolytic, and neuroprotective. Protecting the brain from damage is one of its many benefits. Anxiety, depression, and PTSD are just a few mental health conditions that CBD may help with.

Forms and Methods of CBD Consumption

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CBD can be consumed in various forms, each with its own advantages and disadvantages. Some common forms include:

  • CBD oil, which is extracted from either the marijuana or hemp plant and mixed with a carrier oil such as coconut oil or hemp seed oil
  • Capsules, which are easy to take and provide a consistent dosage
  • Edibles, such as gummies or chocolates, which are a tasty and discreet option
  • Topicals like creams and lotions, which can be applied directly to the skin for localized relief
  • Inhaled through vaping or smoking, which can provide fast-acting and powerful effects

Choosing the right CBD product for your needs depends on factors such as the desired effect, convenience, and personal preference.

The subsequent sections will elaborate on the differences between CBD consumption methods- oral, topical, and inhalation, along with a comparison between full-spectrum and isolate CBD products.

Oral vs. Topical vs. Inhalation

Oral consumption of CBD includes edibles, capsules, and tinctures that can be placed under the tongue for direct absorption into the bloodstream. The onset time for orally consumed CBD is usually around 20-30 minutes, but its bioavailability can vary depending on factors like food consumption.

Topical application of CBD involves creams, lotions, and balms that interact with endocannabinoid receptors found in the skin tissue. The bioavailability of topically applied CBD is generally considered low since it doesn’t enter the bloodstream directly but can still provide targeted relief.

Inhalation methods, such as vaping or smoking, provide fast-acting effects and higher bioavailability compared to oral and topical methods. However, these methods may also come with their own set of risks and considerations, so it’s essential to weigh the pros and cons of each method before choosing the best one for you.

Full Spectrum vs. Isolate CBD

Full-spectrum CBD contains:

  • All the cannabinoids and terpenes found in the cannabis plant
  • Cannabinoids, terpenes, and other beneficial compounds extracted from the hemp plant
  • CBD, THC, and other cannabinoids
  • Terpenes like myrcene, limonene, and beta-caryophyllene

Isolate CBD contains only the pure CBD compound.

The “entourage effect” refers to the idea that all the cannabinoids, terpenes, and other compounds in the cannabis plant work together to enhance the benefits of CBD. This synergy may provide more significant therapeutic effects than isolate CBD, which contains only the CBD compound.

CBD Safety and Dosage Considerations for Chronic Pain

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Regarding CBD safety and dosage considerations, it’s vital to stay informed about potential drug interactions and to determine the apt dosage based on individual factors and the condition under treatment. CBD is known to have some possible side effects. These include nausea, fatigue and irritability. It’s also important to note that high doses of CBD may cause abnormalities in liver-related blood tests.

The FDA does not regulate the safety and purity of dietary supplements, including CBD products. Hence, it becomes imperative to consult with a healthcare professional before initiating any CBD regimen, particularly if you’re on other medications.

Drug Interactions with CBD Products

CBD can interact with certain medications, affecting their metabolization in the liver. CBD could influence the level of drugs in your body, like blood-thinning medicines. This is because it may compete for the enzymes that break down these drugs in the liver. Combining cannabinoids with immunotherapy for cancer is also not recommended, as they may not work well together.

Consulting a healthcare professional before combining CBD with other medications is crucial to prevent any drug interactions. This precaution ensures that you can safely enjoy the potential health benefits of CBD without risking adverse effects on your health.


In this blog post, we have explored the fascinating world of CBD and its interaction with our endocannabinoid system. We have covered the potential benefits of CBD in reducing pain and inflammation, improving mental health, and various forms and methods of consumption. It’s essential to be mindful of CBD safety and dosage considerations, including potential drug interactions and finding the right dosage based on individual factors and the condition being treated. As research continues to uncover the full potential of CBD, we can look forward to a future where this natural compound plays an even more significant role in our overall well-being.

Frequently Asked Questions

What does taking CBD do to your body?

Taking CBD may help with anxiety, insomnia, pain, substance use disorder and depression. However, there can be side effects and it could interact with other medications, so it's important to speak with a doctor before trying it.

How does CBD make you feel first time?

When taking CBD, you can expect to feel relaxed both mentally and physically. Most people report a calming sensation that helps them focus and reduce stress levels. In essence, it's like having your own personal 'chill pill'!

Does CBD oil make you feel spacey?

No, CBD oil does not make you feel “spacey” as it is non-psychoactive and does not produce a high.

What is the difference between CBD and THC?

CBD is non-psychoactive, so it won't get you high like THC will. CBD is derived from cannabis plants while THC is the psychoactive compound responsible for the high sensation.

How does CBD interact with the endocannabinoid system?

CBD interacts with the endocannabinoid system by binding to CB1 and CB2 receptors, modulating various physiological processes.

About MDBio Wellness

Our products originate with our Board-Certified Medical Doctors, whose lifelong mission throughout their careers has been to maximize positive patient outcomes and minimize harm. We rely on the doctors who founded MDbio, and they in turn rely on the latest in modern medical science (including plant-based medicines derived from “non-Western” sources) to inform all of our products.

All our products are carefully formulated to maximize benefits though the synergistic effects of selected ingredients. Our botanical ingredients engage the body’s own endocannabinoid system to allow maximum uptake of phytocannabinoids, making the formula more effective overall.

We source our ingredients strictly from reputable farms and suppliers. All our botanicals are grown by experienced cultivators and are free of heavy metals and pesticides. We use the highest possible, safe concentrations of ingredients to ensure that each formula provides optimal therapeutic value. All raw ingredients are laboratory tested before going into production. 

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Meet the Doctors

Babak Larian, MD, FACS

Dr. Babak Larian, Clinical Chief at Cedars-Sinai Medical Center, is a renowned expert in minimally invasive head and neck surgery. Board-certified and active in global medical missions, he also oversees surgical operations at the La Peer Surgery Center and PathMD pathology laboratories.

Dr. Kiarash Michel, MD

Dr. Kia Michel, a globally acclaimed Urological Oncological Surgeon, founded the Comprehensive Urology Medical Group in Los Angeles, known for his expertise in robotic and minimally invasive therapies. Alongside his medical achievements, he contributes to businesses like La Peer Surgery Center, finding joy in nature and bringing smiles to loved ones.

Kamran Jamshidinia, DPM, FACFAS

Dr. Jamshidinia, a certified Foot and Ankle Surgeon and Fellow of the American College of Foot and Ankle Surgeons, founded Tower Foot & Ankle Surgery and co-founded successful enterprises, including La Peer Health Systems. His involvement in medical research and the cannabinoid medicine market, highlights his multifaceted contributions to the field.

Siamak Tabib, MD

Dr. Siamak Tabib, a Board-Certified Gastroenterologist in Beverly Hills, holds a medical degree from UCLA Geffen School of Medicine and serves as Assistant Clinical Professor at UCLA.

He actively contributes to research in digestive diseases, co- founding healthcare entities and advocating for adaptive sports opportunities through his advisory role at Angel City Sports.

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